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Ulnar artery vasculopathy: a common but nonspecific feature of systemic sclerosis

Abstract IntroductionSystemic sclerosis (SSc) is characterized by microvascular abnormalities and fibrosis. Several studies have reported that large vessel disease is also common in SSc. The aim of this case series was to investigate whether ulnar artery involvement in patients with SSc is a disease-specific phenomenon, as compared to other connective tissue diseases (CTD). MethodsA total [...]

Ulnar artery vasculopathy: a common but nonspecific feature of systemic sclerosis2017-09-15T11:18:22+00:00

Use of intravenous epoprostenol as a treatment for the digital vasculopathy associated with the scleroderma spectrum of diseases

Abstract IntroductionIntravenous prostanoid therapy is recommended for severe systemic sclerosis-related digital vasculopathy. The evidence supporting this recommendation is limited. The aim of this study was to evaluate the safety and efficacy of treating scleroderma spectrum digital vasculopathy with intravenous epoprostenol. MethodsPatients with a diagnosis of systemic sclerosis who had received intravenous epoprostenol for scleroderma spectrum [...]

Use of intravenous epoprostenol as a treatment for the digital vasculopathy associated with the scleroderma spectrum of diseases2017-09-15T11:11:28+00:00

A randomized, single-blinded cross-over trial of ischemic preconditioning in Raynaud’s phenomenon

A randomized, single-blinded cross-over trial of ischemic preconditioning in Raynaud’s phenomenon Abstract IntroductionIschemic preconditioning (IPC) is protective against future ischemia, with brief cycles of ischemia and reperfusion leading to the release of circulating endogenous compounds from ischemic cells. IPC may increase vasodilatory substances and improve Raynaud’s phenomenon (RP). We hypothesized that IPC would be more [...]

A randomized, single-blinded cross-over trial of ischemic preconditioning in Raynaud’s phenomenon2017-09-15T11:07:46+00:00

Certainties and uncertainties concerning the contribution of pericytes to the pathogenesis of systemic sclerosis

Certainties and uncertainties concerning the contribution of pericytes to the pathogenesis of systemic sclerosis Abstract The role of pericytes in systemic sclerosis (SSc) is unclear because of the difficulty in phenotyping them. They are mainly distributed in the pre-capillary, capillary and post-capillary abluminal side of non-muscular micro-vessels, express platelet-derived growth factor receptors (PDGFRs), and preside [...]

Certainties and uncertainties concerning the contribution of pericytes to the pathogenesis of systemic sclerosis2017-09-15T11:00:55+00:00

Paul Klee’s illness – a series of historical and clinical vignettes

Paul Klee’s illness – a series of historical and clinical vignettes Post author correction Article Type: BRIEF REPORT Article Subject: Psychology and Social Phenomena DOI:10.5301/jsrd.5000248 Authors Richard M. Silver Abstract Paul Klee (1879-1940) is undoubtedly the most notable historical figure to have suffered from systemic sclerosis (scleroderma). In this, the first in a series of [...]

Paul Klee’s illness – a series of historical and clinical vignettes2017-08-11T13:58:46+00:00

Differential expression of hepatocyte growth factor in patients with systemic sclerosis-associated pulmonary arterial hypertension

Differential expression of hepatocyte growth factor in patients with systemic sclerosis-associated pulmonary arterial hypertension Post author correction Article Type: BRIEF REPORT Article Subject: Epidemiology and Diagnostic Methods DOI:10.5301/jsrd.5000245 Authors Yon K. Sung, Roham T. Zamanian, Catriona A. Wagner, William Robinson, Virginia Steen, Lorinda Chung Abstract IntroductionNon-invasive biomarkers are needed to identify pulmonary arterial hypertension (PAH) [...]

Differential expression of hepatocyte growth factor in patients with systemic sclerosis-associated pulmonary arterial hypertension2017-08-11T13:57:01+00:00

Prevalence and incidence of pulmonary arterial hypertension: 10-year follow-up of an unselected systemic sclerosis cohort

Prevalence and incidence of pulmonary arterial hypertension: 10-year follow-up of an unselected systemic sclerosis cohort Post author correction Article Type: ORIGINAL RESEARCH ARTICLE Article Subject: Epidemiology and Diagnostic Methods DOI:10.5301/jsrd.5000246 Authors Els Vandecasteele, Karin Melsens, Kristof Thevissen, Michel De Pauw, Ellen Deschepper, Saskia Decuman, Yves Piette, Filip De Keyser, Guy Brusselle, Vanessa Smith Abstract IntroductionEarly [...]

Prevalence and incidence of pulmonary arterial hypertension: 10-year follow-up of an unselected systemic sclerosis cohort2017-08-11T13:52:10+00:00

Validity of the PROMIS-29 in a large Australian cohort of patients with systemic sclerosis

Validity of the PROMIS-29 in a large Australian cohort of patients with systemic sclerosis Post author correction Article Type: ORIGINAL RESEARCH ARTICLE Article Subject: Epidemiology and Diagnostic Methods DOI:10.5301/jsrd.5000243  Link Validity of the PROMIS-29 in a large Australian cohort of patients with systemic sclerosis Authors Kathleen Morrisroe, Wendy Stevens, Molla Huq, Joanne Sahhar, Gene-Siew Ngian, [...]

Validity of the PROMIS-29 in a large Australian cohort of patients with systemic sclerosis2017-08-11T09:59:09+00:00

Functional autoantibodies directed against cell surface receptors in systemic sclerosis

Functional autoantibodies directed against cell surface receptors in systemic sclerosis Post author correction Article Type: REVIEW Article Subject: Clinical Conditions and Organ Involvement DOI:10.5301/jsrd.5000241 Link: Functional autoantibodies directed against cell surface receptors in systemic sclerosis Authors Otavio Cabral-Marques, Gabriela Riemekasten Abstract Systemic sclerosis (SSc) is a complex and heterogeneous systemic autoimmune disease characterized by the [...]

Functional autoantibodies directed against cell surface receptors in systemic sclerosis2017-08-11T09:43:54+00:00